Actors,
1. Kevin Spacey
Best Roles: American Beauty, LA Confidential, Se7en, The Usual Suspects
2. Johnny Depp
Best Roles: Pirtes of the Caribbean, Finding Neverland, Edward Scissorhands
3. Brad Pitt
Best Roles: Fight Club, Se7en
One to Watch: Joseph Gordon Levitt, excellent in Brick and Mysterious Skin
Actresses,
1. Audrey Tautou
Best Roles: Amelie, A Very Long Engagement
2. Natalie Portman
Best Roles: Leon, Garden State
3. Alison Lohman
Best Roles: Matchstick Men, Where the Truth Lies, White Oleander
One to Watch: Ellen Page, excellent in Hard Candy, wasn't so good in X-men 3: The Last Stand, but she's going back to doing more interesting roles.